Get health-related assistance without delay for those who recognize any of the subsequent: slow/shallow respiration, intense drowsiness/problem waking up, confusion.

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers lower than six many years of age, due to the fact the combination may possibly result in fatal respiratory depression In this particular age population. It is necessary that promethazine with codeine syrup is calculated with an precise measuring unit (see Safety measures-Details For Sufferers).

Animal copy scientific studies have not been performed with the drug mixture-promethazine and codeine. It's not necessarily recognised whether or not this drug mix could cause fetal hurt when administered to your pregnant lady or can influence replica ability.

When useful for an extended time, this medication may well not operate too and should need different dosing. Converse with your medical doctor if this medication stops Performing very well.

The amount of medicine which you choose is determined by the energy on the drugs. Also, the quantity of doses you take every day, the time authorized amongst doses, and also the length of time you take the medication depend on the health care problem for which you happen to be utilizing the medicine.

This medicine might trigger many people to be dizzy, lightheaded, drowsy, or a lot less inform than They are really Typically. Even when taken at bedtime, it may lead to many people to experience drowsy or much less inform on arising.

Anticholinergics – Concomitant utilization of other agents with anticholinergic Houses should be carried out with caution.

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Do not just take this medication for numerous times just before allergy tests mainly because take a look at success might be afflicted.

Promethazine hydrochloride occurs to be a white to faint yellow, pretty much odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air.

Really serious, life-threatening, or fatal respiratory melancholy has actually been reported with the use of opioids, which includes codeine, on the list of Lively ingredients in Promethazine with Codeine Oral Answer. Codeine generates dose-linked respiratory despair by instantly performing on the brain stem respiratory center that controls respiratory rhythm and may deliver irregular and periodic breathing. Codeine is subject to variability in metabolism primarily based upon CYP2D6 genotype, which can result in an increased exposure to the active metabolite morphine [see WARNINGS AND Safety measures (five.three)]. Promethazine exerts a depressant effect on the respiratory Middle which is independent of and additive to that of other respiratory depressants, such as codeine [see WARNINGS AND PRECAUTIONS (five.

Take into account that this medication is prescribed mainly because your health practitioner has judged that the reward to you personally is bigger than the risk of Uncomfortable side effects. Lots of people employing this medication would not have serious Uncomfortable side effects.

The concomitant utilization of Promethazine with Codeine Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may possibly result in decreased codeine amounts, greater norcodeine stages, and fewer metabolism by way of 2D6 with resultant reduced morphine degrees. This can be associated with a reduce in efficacy, and in a few people, might lead to signals and signs or symptoms of opioid withdrawal.

Excessively big dosages of antihistamines, including promethazine hydrochloride, get more info in pediatric people may possibly result in unexpected Demise (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric clients. In pediatric sufferers who will be acutely sick related with dehydration, You can find a heightened susceptibility to dystonias with using promethazine HCl.